ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific mannerArticle Published on 2022-11-052022-11-16 Journal: Communications Biology [Category] SARS, 변종, [키워드] accumulated ACE2 ACE2 receptor binding binding site caused cellular changes in conserved Delta glycan glycosylation glycosylation deletion glycosylation site Guidance Interaction investigated lineages modulate mutated N-glycosylation omicron parental profile provide SARS-CoV-2 SARS-CoV-2 spike protein soluble ACE2 spike spike mutation the SARS-CoV-2 therapeutic use variant variants of concern virus VOCs [DOI] 10.1038/s42003-022-04170-6 PMC 바로가기
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cellsArticle Published on 2022-11-012022-11-15 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 진단, [키워드] 16HBE 16HBE cell 16HBE cells 6-O-angeloylplenolin ACE2 ACE2 expression addition administration Cell Centipeda Centipeda minima chemokine Chinese Compound conducted COVID-19 CX3CL1 CXCL13 dataset demonstrated downregulated entry of SARS-CoV-2 enzyme evaluated expression gene encoding HLF IL-6 inhibited inhibitor Interaction lung epithelial cell Lung epithelial cells lung tissue lung tissues mice modulate parental pathogen phosphorylated positively correlated promoter PROTECT Protein pseudovirus receptor reduced regulate Regulation S protein SARS-CoV-2 SARS-COV-2 infection screened STAT3 STAT3. stimulated suppressed target cells tested TFS Transcription transcription factor transfected with [DOI] 10.1038/s41401-022-00906-6 PMC 바로가기
Evolution of naturally arising SARS-CoV-2 defective interfering particlesArticle Published on 2022-10-272022-11-16 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, [키워드] addition anti-viral agents arising can be used defective viral genome fusion protein gene delivery Genome identify Infection interfere multiplicity of infection parental Particle passaging of SARS-CoV-2 Replication SARS-CoV-2 selected synthetic the SARS-CoV-2 genome variant viral replication virus virus propagation [DOI] 10.1038/s42003-022-04058-5 PMC 바로가기
Intranasal administration of cold-adapted live-attenuated SARS-CoV-2 candidate vaccine confers protection against SARS-CoV-2Article Published on 2022-10-022022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 진단, [키워드] administration animal model attenuate Attenuated vaccines can be used candidate vaccine cleavage COVID-19 COVID-19 pandemic Deletion elicit examined furin cleavage site furin protease glycoprotein hamster hamsters histopathological Host Immunity Infection lesion motif mucosal neutralizing antibody parental pathogenesis of SARS-CoV-2 polybasic protective immunity proteolytic reduce required robust S1/S2 S1/S2 glycoprotein SARS-CoV-2 SARS-CoV-2. sequence Spike protein subsequent suggested unique Vaccine virus wild-type WT SARS-CoV-2 [DOI] 10.1016/j.virusres.2022.198857 PMC 바로가기
Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 VariantsArticle Published on 2022-10-012022-11-16 Journal: The protein journal [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 adopted affinity antibody biochemical characterization Degradation help host cell receptor host receptor immune response immunological IMPROVE increase in infected individual interact Intervention medical intervention mutant Mutation mutations natural selection neutralizing antibody parental protease Rapid RBD receptor Receptor binding domain responses SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant sensitivity the RBD thermal stability Transmissibility understanding variant variants of concern variants. [DOI] 10.1007/s10930-022-10073-6 PMC 바로가기
Too Healthy to Fall Sick? Longevity Expectations and Protective Health Behaviours during the First Wave of COVID-19Research article Published on 2022-10-012022-10-05 Journal: Journal of Economic Behavior & Organization [Category] 유전자 메커니즘, [키워드] age Ageing assessment Care Characteristics conditions COVID-19 death decrease engage estimate Europe exhibiting expectation expected forgone medical treatment Gender Health Health behaviours health capital Health status healthy Hypothesis increase increase in individual level individuals information instrumental variables less Longevity longevity expectations pandemic parental private information Probability Protective Protective behaviours retirement risk share sick social distancing Standard deviation survey Treatment Wave [DOI] 10.1016/j.jebo.2022.08.015 [Article Type] Research article
Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadthArticle Published on 2022-09-222022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] activity antibodies antibody antibody cocktail antibody resistance binding breadth computational simulation costly COVID-19 crosslinking cryo-EM Engineering epitope exhibit IMPROVE Infection mouse model Neutralizing Neutralizing activity parental RBD reduce SARS-CoV-2 SARS-CoV-2 variant the receptor-binding domain therapeutic efficacy therapy variants virus-neutralizing X-ray crystallography [DOI] 10.1038/s41467-022-33284-y PMC 바로가기
Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infectionArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] absence acute respiratory syndrome Administered administration animal model blocked bronchoalveolar C57BL/6 caused CD4 CD8 coronavirus Coronavirus disease-19 COVID-19 COVID-19 progression current demonstrated effective Efficacy elicited evaluated expressing full-length histopathological IgA antibody IgG immune responses Immunity immunogenic immunogenicity induce intramuscular intranasal intranasal delivery K18-hACE2 transgenic mice Local lung lung lesion lymph nodes mice modified vaccinia virus morbidity and mortality mucosal mucosal immune MVA nasal washe Nasal washes neutralizing antibody parental Prevent pro-inflammatory cytokine PROTECT Protective protective efficacy Protein responses Result S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2-specific immune response serum single dose spleen susceptible systemic immune response systemically T-cell immune response the SARS-CoV-2 Transmission undetectable upper respiratory tract vaccination Vaccine vaccine administration vaccine candidate vaccine candidates vaccine candidates. vaccine dose virus infection [DOI] 10.3389/fimmu.2022.995235 PMC 바로가기
Loneliness in pregnant and postpartum people and parents of children aged 5 years or younger: a scoping reviewArticle Published on 2022-09-072022-11-15 Journal: Systematic Reviews [Category] 치료제, [키워드] Adults children CINAHL Cochrane Library Collection conducted core COVID-19 pandemic Depression detect Effect Elsevier Evidence Health Healthcare professional help highest identify incidence inclusion criteria increase inquiry instance loneliness Loneliness in parenthood Loneliness in pregnancy Maternal Maternal loneliness Mental nine Older Open Science Framework OVID parent parental Parental loneliness parents Perinatal Perinatal loneliness populations Pregnancy pregnant Prevalence ProQuest protocol PsycINFO ranged Research risk scoping review. sensitive indicator study participant Topic was measured Web of Science [DOI] 10.1186/s13643-022-02065-5 PMC 바로가기
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variantsArticle Published on 2022-09-072022-10-06 Journal: Science Translational Medicine [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Administered Anti-SARS-CoV-2 Activity antiviral drug antiviral efficacy antiviral potency coronavirus coronavirus disease COVID-19 delta variant demonstrated driving Efficacy exhibited GS-441524 in vitro K18-hACE2 mice lung damage Mouse models oral administration oral bioavailability pandemic parent nucleoside parental prophylactically reduced viral load Remdesivir SARS-CoV-2 SARS-CoV-2 transmission vaccination variant variants of concern virus VoC VOCs [DOI] 10.1126/scitranslmed.abm7621 PMC 바로가기 [Article Type] Article